Astaxanthin is a carotenoid with potent antioxidant and anti-inflammatory activity. It is found in crustaceans, such as shrimps and crabs, and fish, such as salmon and sea bream. The anti-inflammatory activity of astaxanthin, which is based on its antioxidant properties, has been implicated in improving lifestyle-related diseases and managing health. Furthermore, astaxanthin has anti-aging effects.
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Astaxanthin is a promising compound in the field of dermatology. It inhibits collagenases, MMP activity, inflammatory mediators, and ROS induction, resulting in potent antiwrinkle and antioxidant effects.
Moreover, astaxanthin may prevent UV-induced immunosuppression. Toxicological aspects have been characterized and astaxanthin appears to be a safe and bioavailable compound.
CLINICAL STUDIES AND RESEARCH
Oxidative stress plays a critical role in skin aging and damage. The mechanisms of aging include oxidative metabolism and exposure to sun UV light. Oxidant events of skin aging involve damage to DNA, inflammatory response, reduced production of antioxidants, and generation of matrix metalloproteinases that degrade collagen and elastin in the skin.
(1) Sergio Davinelli,1,* Michael E. Nielsen,2 and Giovanni Scapagnini1 | Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946307/
(2) Kumi Tominaga,1,* Nobuko Hongo,1 Mayuko Fujishita,1 Yu Takahashi,1 and Yuki Adachi1 | Protective effects of astaxanthin on skin deterioration. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525019/
(3) Robert G. Fassett1,2,* and Jeff S. Coombes2 | Astaxanthin: A Potential Therapeutic Agent in Cardiovascular Disease. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083660/
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